INFRA ENTRYPOINT

16 9f 4F 67 53 8⣀⣠⣤⡶⠖⠒⢒⣤⣤⣄⣀A9 A9 DC f0 7f 14 23
b2 6d 6F 72 9⢀⣴⣾⣿⣿⣵⣿⣿⣿⣿⣿⣿⣿⣿⣿⣶⣄⡀8 8F b1 df 51 b8
06 b5 00 0F⢀⣼⡿⢋⡌⣿⣿⣿⣿⣿⣿⣿⣿⣿⣿⣿⣿⣿⣿⣿⣦ 81 e3 f4 eb 81
4f 2d 01 D⢀⣾⠟⣴⣿⣷⡘⣿⣿⣿⣿⣿⣿⣿⣿⣿⣿⣿⣿⣿⣿⣿⣷⡘8 65 fa 12 aa
85 65 68 F⣾⡏⣼⣿⣿⣿⣷⡜⢿⣿⣿⣿⣿⣿⣿⣿⣿⣿⣿⣿⣿⣿⣿⣷A c9 d7 fd ee
b8 63 53 ⢸⣿⢁⢿⣿⣿⣿⣿⠿⠆⠹⢿⣿⣿⣿⣿⣿⣿⣿⣿⣿⣿⣿⣿⣿⡆ cb 16 99 fb
36 79 39 ⣼⡿⠸⢷⣿⣿⣿⣿⣿⣿⡿⢮⡻⢿⡿⢿⣿⣿⣿⣿⣿⣿⣿⣿⣿⡇ d5 2b 49 a4
9f 87 D9 ⣿⡄⢠⢄⡉⢹⣿⣿⣿⣿⢃⣠⢌⡀⠙⢮⡻⣿⣿⣿⣿⣿⣿⣿⣿⡇ cb 15 ee 29
df 31 3D ⣿⡇⣼⢸⡿⣸⣿⣿⣿⣿⣿⢃⣿⣿⣷⠀⢨⣽⣿⣿⣿⣿⣿⣿⣿⡇ 2d 50 60 48
53 23 64⢰⣿⠃⣿⡌⣵⣿⣿⣿⣿⣿⣿⣎⠿⠿⣫⠇⣾⣿⣿⣿⣿⣿⣿⣿⡟0 50 ef e7 56
23 9e 31⢸⡿⢸⣿⣿⣿⣿⣿⣿⣿⣿⣿⣿⣿⣟⣿⢸⣿⣿⣿⣿⣿⣿⣿⣿⡇8 06 23 6d 65
a9 99 58⣼⣧⢸⣿⣿⣿⣿⣿⣿⣿⣿⣿⣿⣿⣿⡇⣾⣿⣿⡿⣿⣿⣿⣿⣿⠁D a8 23 7c b8
a2 80 8F⣿⣿⣆⢻⣿⣿⣷⣾⣿⣿⣿⣿⣿⣿⣿⢡⣿⣿⣿⣇⣿⣿⣿⣿⣿B9 03 cd de 8f
90 c2 1⢰⣿⣿⣿⣦⠹⣿⣿⣿⣿⣿⣿⣿⡿⠟⠉⢸⣿⣿⡏⢿⣿⣿⣿⣿⣿A6 10 94 77 11
58 d7 D⣸⢻⣿⣿⣿⢀⡜⠿⠿⠿⢛⣋⠁ 0F⣿⣿⣿⠀⢸⣿⣿⣿⣿⣿DD ff 6f 41 bc
2c cf F⣿⢸⣿⣿⣿⣿⣿⣿⣶⣿⣿⣿⡆ 0F⣿⣿⡿⠀⣸⣿⣿⣿⣾⣿⡇F 5a 66 6d aa
51 16 8⣿⢸⣿⣿⣿⣿⣿⡿⠛⠛⠉⠉⠁ 0F⣿⢿⣇⠀⠿⣿⣿⣿⣿⣿⣷F 9b bb ea 22
6d cf ⢸⣿⢸⣿⣿⢿⣿⠋ 0F 0F 0F⢳⠊⢿⡌⢸⣿⣿⣿⣿⣿⣿⡆ 4c b1 69 9f
58 4e ⢸⣿⣸⣿⣿⢸⠇F 0F 0F 0F ⠑⡘⠿⠄⡽⣿⣿⣿⣿⣿⣿⡀e3 7e c9 5c
d6 10 ⠸⣿⡟⣿⣿⡌0F 0F 0F 0F 0F 0⢱⠹⣿⣿⣿⣿⣿⣧17 f5 e9 13
30 72 2⣿⣷⣏⣿⡇0F 0F 0F 0F 0F 0F⡑⠘⢿⣿⣿⣿⣿24 13 34 cc
ce 0d 3⢹⣿⣿⣸⠁0F 0F 0F 0F 0F 0F 0⠈⠻⢿⡝⢿1d 7a 0e bf
    

Source Forges/Code
├─ Forgejo https://git.fem.gg/cafkafk
└─ GitHub  https://github.com/cafkafk

Social Media
├─ Fedi https://catgirl.farm
└─ Blog https://cafkafk.dev

Infra
└─ Status https://uptime.fem.gg

Contact
└─ Matrix @cafkafk:fem.gg

    

Estrogen (British English: oestrogen; see spelling differences) is a category of
sex hormone responsible for the development and regulation of the female
reproductive system and secondary sex characteristics.[1][2] There are three
major endogenous estrogens that have estrogenic hormonal activity: estrone (E1),
estradiol (E2), and estriol (E3).[1][3] Estradiol, an estrane, is the most
potent and prevalent.[1] Another estrogen called estetrol (E4) is produced only
during pregnancy.

Estrogens are synthesized in all vertebrates[4] and some insects.[5]
Quantitatively, estrogens circulate at lower levels than androgens in both men
and women.[6] While estrogen levels are significantly lower in males than in
females, estrogens nevertheless have important physiological roles in males.[7]

Like all steroid hormones, estrogens readily diffuse across the cell membrane.
Once inside the cell, they bind to and activate estrogen receptors (ERs) which
in turn modulate the expression of many genes.[8] Additionally, estrogens bind
to and activate rapid-signaling membrane estrogen receptors (mERs),[9][10] such
as GPER (GPR30).[11]

In addition to their role as natural hormones, estrogens are used as
medications, for instance in menopausal hormone therapy, hormonal birth control
and feminizing hormone therapy for transgender women, intersex people, and
nonbinary people.

Synthetic and natural estrogens have been found in the environment and are
referred to as xenoestrogens. Estrogens are among the wide range of
endocrine-disrupting compounds (EDCs) and can cause health issues and
reproductive disfunction in both wildlife and humans.[12][13]

The four major naturally occurring estrogens in women are estrone (E1),
estradiol (E2), estriol (E3), and estetrol (E4). Estradiol (E2) is the
predominant estrogen during reproductive years both in terms of absolute serum
levels as well as in terms of estrogenic activity. During menopause, estrone is
the predominant circulating estrogen and during pregnancy estriol is the
predominant circulating estrogen in terms of serum levels. Given by subcutaneous
injection in mice, estradiol is about 10-fold more potent than estrone and about
100-fold more potent than estriol.[14] Thus, estradiol is the most important
estrogen in non-pregnant females who are between the menarche and menopause
stages of life. However, during pregnancy this role shifts to estriol, and in
postmenopausal women estrone becomes the primary form of estrogen in the body.
Another type of estrogen called estetrol (E4) is produced only during pregnancy.
All of the different forms of estrogen are synthesized from androgens,
specifically testosterone and androstenedione, by the enzyme aromatase.

Minor endogenous estrogens, the biosyntheses of which do not involve aromatase,
include 27-hydroxycholesterol, dehydroepiandrosterone (DHEA), 7-oxo-DHEA,
7α-hydroxy-DHEA, 16α-hydroxy-DHEA, 7β-hydroxyepiandrosterone, androstenedione
(A4), androstenediol (A5), 3α-androstanediol, and 3β-androstanediol.[15][16]
Some estrogen metabolites, such as the catechol estrogens 2-hydroxyestradiol,
2-hydroxyestrone, 4-hydroxyestradiol, and 4-hydroxyestrone, as well as
16α-hydroxyestrone, are also estrogens with varying degrees of activity.[17] The
biological importance of these minor estrogens is not entirely clear.